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Clinical Research Studies - Connecticut Clinical Research Center


Our site has extensive experience in conducting clinical trials in the following areas:

To learn more about recruiting studies, Please contact us at 203-754-3588 or e-mail us at ccrcinfo@ctclinicalresearchcenter.com

To learn more about some of the studies and research terminology you may visit the following websites:

http://www.centerwatch.com/patient/glossary.html

http://clinicaltrials.gov/

 

Benign Prostatic Hyperplasia (BPH)
Benign prostatic hyperplasia (BPH) also is called enlarged prostate. BPH is a non-cancerous enlargement of the prostate gland. Changing hormone levels occurring with age causes BPH. This often occurs around the age of 50. Excess tissue can block the urethra, causing various symptoms such as:

  • Difficulty urinating
  • The enlarged prostate can also press on the bladder, so you may need to urinate more often
  • Straining during urination
  • A weak urine stream
  • Feeling that the bladder isn’t emptying all the way

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Bladder Cancer
Bladder cancer usually originates in the bladder lining, which consists of a mucous layer of surface cells. Tumors are categorized as low-stage (superficial) or high-stage (muscle invasive). More than 90% of cases originate in the transitional epithelial cells (transitional cell carcinoma).

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Erectile Dysfunction (ED)
Erectile dysfunction (ED) is also called impotence. Erectile dysfunction (ED) is the inability of a man to achieve or maintain an erection sufficient for his sexual needs or the needs of his partner. Many men experience this at some point in their lives. Some men, experience chronic, complete erectile dysfunction (impotence), and others, partial or brief erections. Frequent erectile dysfunction can cause emotional and relationship problems, and often leads to diminished self-esteem. Erectile dysfunction has many causes, most of which are treatable, and is not an inevitable consequence of aging.

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Female Sexual Dysfunction (FSD)
FSD may be classified under one or more categories including Desire, Arousal, Orgasmic and Pain Disorders. The common causes of FSD are decreased blood supply to the clitoris, complications of nerve or spinal cord surgery, or consequences of chronic medical conditions or medications

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Hypogonadism
Hypogonadism is also known as Testosterone Deficiency. Testosterone production declines naturally with age. Low testosterone, may result from disease or damage to the hypothalamus, pituitary gland, or testicles that inhibit hormone secretion and testosterone production. Depending on age, insufficient testosterone production can lead to abnormalities in muscle and bone development, and diminished libido and depression.

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Incontinence
Incontinence is the loss of voluntary control over urinary functions. There are many types of urinary incontinence:

  • Stress
    Losing urine involuntarily during certain physical activities: coughing, laughing or sneezing; lifting; walking or performing other forms of exercise; moving to get up from a chair or out of bed.
  •  Urge
    Inability to control the sudden urge to urinate. A large amount of urine may be released. Urge incontinence may occur after a sudden change in position or activity.
  • Mixed
    A mixture of stress and urge incontinence.

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Interstitial Cystitis (IC)
Interstitial cystitis (IC) is a chronic inflammatory condition of the bladder that can cause frequent, urgent, and painful urination with or without pelvic discomfort.

Women with IC typically complain of pain or pressure in the pelvic area, pain during or after sex, and frequent, sometimes painful, urination. In addition, women with IC are typically diagnosed with urinary tract infections.

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Over Active Bladder (OAB)
In people with an overactive bladder (OAB), the detrusor muscle (bladder muscle) contracts spastically, sometimes without a known cause, which results in sustained, high bladder pressure and the urgent need to urinate (called urgency). Everyone is different, but the most common signs of overactive bladder are a sudden urgency, frequency and leakage.

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Peyronie’s Disease (PD)
Peyronie's disease is characterized by the formation of hardened tissue (fibrosis) in the penis that can cause pain, curvature, and distortion during erection. The penis is composed of two columns of erectile tissue (the corpora cavernosa) and the corpus spongiosum, which contains the tube that carries urine and semen from the body (urethra). In PD, a scar (plaque) forms on the sheath surrounding the corpora cavernosa.

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Premature Ejaculation (PE)
Premature ejaculation (PE) is a term used to describe a condition in which a man regularly ejects semen (i.e., ejaculates) soon after the onset of sexual arousal, or sooner than he or his partner wishes. This condition, which is also called rapid ejaculation, is the most common type of sexual dysfunction in men under the age of 40.

Premature ejaculation can be primary (in men who have had the condition since puberty), or secondary (acquired; in men who previously had control of ejaculation). It may develop in men who have ED and are anxious about maintaining an erection during sexual intercourse.

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Prostate Cancer
Adenocarcinoma of the prostate is the clinical term for a cancerous tumor on the prostate gland. As prostate cancer grows, it may spread to distant parts of the body (e.g., bones, liver). Prostate cancer confined to the gland often is treated successfully. Most Men with prostate cancer can enjoy a long relatively healthy life.

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Prostatitis
Prostatitis is also known as Chronic Pelvic Pain in men. Prostatitis is a term used to describe inflammatory conditions of the prostate gland. It is thought that most cases of prostatitis result from bacterial infection, but evidence of infection is not always found. An infected or inflamed prostate can cause painful urination and ejaculation, urinary frequency and urgency, and if left untreated, chronic, recurrent symptoms.

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Sperm Assessments
This is usually done in the course of a fertility evaluation, or to determine if sperm are absent following a vasectomy. Research studies are usually done to evaluate if a study drug has any effect on sperm.

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Urinary Tract Infection (UTI)
Urinary tract infection (UTI) is a common infection that usually occurs when bacteria enter the urethra and multiply in the urinary tract. The urinary tract includes the kidneys, the tubes that carry urine from the kidneys to the bladder (ureters), bladder, and the tube that carries urine from the bladder (urethra). Men, women, and children develop UTIs.

Urinary tract infections usually develop first in the lower urinary tract (urethra, bladder) and, if not treated, can progress to the upper urinary tract (ureters, kidneys). Bladder infection (cystitis) is by far the most common UTI. Kidney infection (pyelonephritis) requires urgent treatment and can lead to reduced kidney function if left untreated.

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